The NALM-6 mannequin, a useful software in preclinical leukemia analysis, entails the implantation of human acute lymphoblastic leukemia cells into immunodeficient mice. This creates a residing system that mirrors the development and response to remedy seen in human leukemia, permitting researchers to review the illness and check potential therapies in a extra managed surroundings.
This mannequin’s growth supplied researchers with a essential platform for testing new therapies and learning leukemia growth. It permits for detailed evaluation of illness development, drug resistance mechanisms, and the interplay between leukemia cells and the microenvironment. The power to check potential therapies in vivo earlier than medical trials affords a extra environment friendly and moral method to drug growth, contributing to the development of leukemia remedy.